Clozapine treatment, eosinophilia and agranulocytosis

Agranulocytosis during Clozapine Therapy

Sir, This is in response to the article' Do Indian researchers read Indian research? a reappraisal, four years later', published in April 2000 (No.2, f Vol.42) issue of your journal. The authors of this article have documented their observations on my article 'Transsexualism in Schizophrenia : a case report' (April, 1998, Vol.40, No.2) that I did not refer to their article, 'Behaviour Therapy f...

report of one case of agranulocytosis after clozapine treatment

introduction : clozapine is the first effective antipsychotic drug with the least extra pyramidal side effects and more agranulocytosis than other standard neuroleptics. granolocytopenia or agranulocytosis occurs in 1 to 2 percent of all patients treated with clozapine. agranulocytosis due to clozapine is a fatal disorder that requires immediate clinical intervention.   method : this paper repo...

Clozapine-induced agranulocytosis after 11 years of treatment.

http://ajp.psychiatryonline.org 2. Narendran R, Young CM, Valenti AM, Nickolova MK, Pristach CA: Is psychosis exacerbated by modafinil? (letter). Arch Gen Psychiatry 2002; 59:292–293 3. Spensley J, Rockwell DA: Psychosis during methylphenidate abuse. N Engl J Med 1972; 286:880–881 4. Leong GB, Shaner AL, Silva JA: Narcolepsy, paranoid psychosis, and analeptic abuse. Psychiatr J Univ Ott 1989; 1...

Clozapine, agranulocytosis, and benign ethnic neutropenia.

C lozapine is an atypical antipsychotic that is effective in treatment resistant schizophrenia. The National Institute for Health and Clinical Excellence (NICE) guidelines for schizophrenia specify that ‘‘in individuals with evidence of treatment resistant schizophrenia, clozapine should be introduced at the earliest opportunity’’. A severe adverse effect of clozapine that limits its more wides...

Biological mechanisms behind clozapine-induced agranulocytosis